| 泻火消瘿方对心肝火旺证Graves病患者细胞免疫功能的影响 |
| Effect of Xiehuo Xiaoying decoction on cellular immune function in Graves’ disease patients with heart and liver fire flaming syndrome |
| DOI： |
| 中文关键词: Graves病 泻火消瘿方 心肝火旺证 淋巴细胞亚群 免疫 |
| 英文关键词: Graves" disease Xiehuo Xiaoying Formula syndrome of excessive heart and liver fire lymphocyte subsets immunity |
| 基金项目:江苏省中医药管理局科技项目(国家中医临床基地开放课题重点项目项目编号：JD2022SZXZD03) |
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| 中文摘要: |
| 目的 探讨泻火消瘿方对心肝火旺证Graves病(GD)患者的临床疗效,以及对心肝火旺证GD患者淋巴细胞免疫功能的影响。方法 选取符合纳入标准的心肝火旺证GD患者70例,随机分配到常规治疗组和中药组,每组35例。常规治疗组予甲巯咪唑(MMI)治疗,中药组在MMI治疗上联用泻火消瘿方。连续治疗12周,观察两组患者治疗前后临床症状、中医证候积分、甲状腺功能及相关抗体、淋巴细胞亚群及安全性指标等变化。结果 最终有58例GD患者完成研究,其中常规治疗组30组,中药组28组。中药组在降低中医证候积分方面优于常规治疗组,且不良反应更少。两组GD患者治疗前后外周血淋巴细胞亚群均发生了变化,其中常规治疗组CD4+/CD8+、CD4+T淋巴细胞百分比均较治疗前升高(P＜0.05),而中药组淋巴细胞绝对数目、CD4+T淋巴细胞百分比、CD4+/CD8+、NK 细胞百分比升高,B 细胞百分比降低(P＜0.05),治疗后组间比较显示中药组CD4+/CD8+、NK 细胞百分比较常规治疗组明显升高,B细胞百分比明显降低(P＜0.05)。结论 泻火消瘿方联合MMI治疗对GD临床疗效确切,可有效改善中医临床症状。泻火消瘿方治疗GD的机制与恢复机体免疫有关,通过调节机体淋巴细胞免疫功能,从而达到对GD的治疗作用。 |
| 英文摘要: |
| Objective: To explore the clinical efficacy of the Xiehuo Xiaoying Formula on Graves'' disease (GD) patients with heart and liver fire excess syndrome, as well as its impact on the lymphocyte immune function of these patients. Methods: A total of 70 GD patients with heart and liver fire excess syndrome who met the inclusion criteria were randomly assigned to the conventional treatment group and the traditional Chinese medicine (TCM) group, with 35 cases in each group. The conventional treatment group was treated with methimazole (MMI), while the TCM group was treated with MMI combined with the Xiehuo Xiaoying Formula. The treatment lasted for 12 weeks, and changes in clinical symptoms, TCM syndrome scores, thyroid function and related antibodies, lymphocyte subsets, and safety indicators were observed before and after treatment in both groups. Results: A total of 58 GD patients completed the study, including 30 in the conventional treatment group and 28 in the TCM group. The TCM group was superior to the conventional treatment group in reducing TCM syndrome scores and had fewer adverse reactions. Changes in peripheral blood lymphocyte subsets were observed in both groups of GD patients before and after treatment. In the conventional treatment group, CD4+/CD8+ and the percentage of CD4+ T lymphocytes increased compared with those before treatment (P < 0.05). In the TCM group, the absolute number of lymphocytes, the percentage of CD4+ T lymphocytes, CD4+/CD8+, and the percentage of NK cells increased, while the percentage of B cells decreased (P < 0.05). After treatment, the comparison between the two groups showed that the TCM group had significantly higher CD4+/CD8+ and NK cell percentages and significantly lower B cell percentages than the conventional treatment group (P < 0.05). Conclusion: The combination of the Xiehuo Xiaoying Formula and MMI has a definite clinical effect on GD and can effectively improve the clinical symptoms of TCM. The mechanism of the Xiehuo Xiaoying Formula in treating GD is related to the restoration of the body''s immune function, and it achieves the therapeutic effect on GD by regulating the lymphocyte immune function of the body. |
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