| 华佗再造丸联合丁苯酞治疗痰瘀阻络型脑梗死的临床研究 |
| Huatuo Zaizao Pills Combined with Butylphthalide for Cerebral Infarction with Phlegm-Stasis Occluding Collateral Syndrome: A Randomized Controlled Trial |
| DOI： |
| 中文关键词: 华佗再造丸 丁苯酞 痰瘀阻络证 脑梗死 临床研究 |
| 英文关键词: Huatuo Zaizao Pill butylphthalide phlegm-stasis occluding collateral syndrome cerebral infarction clinical observation |
| 基金项目:广东省中医药局科研项目,项目编号:20241394 |
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| 中文摘要: |
| 目的 探讨华佗再造丸联合丁苯酞对痰瘀阻络型脑梗死患者美国国立卫生研究院卒中量表(NIHSS)评分、动脉粥样硬化指数(AIP)值及Barthel指数(BI)评分的影响。方法 选取2024年1月-2025年4月本院神经内科收治的45例痰瘀阻络型脑梗死患者,随机分为观察组22例和对照组23例,观察组予以华佗再造丸联合丁苯酞治疗,对照组予以丁苯酞治疗。2组疗程均为1个月。比较两组治疗前后NIHSS评分、AIP值及BI评分的差异。结果 治疗1个月后,两组NIHSS评分、AIP值均较治疗前显著降低(P<0.01),且观察组的NIHSS评分及AIP值显著低于对照组(P<0.05)。2组患者BI评分较治疗前显著增加(P<0.01)。结论 华佗再造丸联合丁苯酞可有效抑制动脉粥样硬化进展,改善神经功能缺损。 |
| 英文摘要: |
| Objective To explore the effects of Huatuo Zaizao Pills combined with butylphthalide on the National Institutes of Health Stroke Scale (NIHSS) score, Atherosclerosis Index (AIP) value, and Barthel Index (BI) score in patients with phlegm and blood stasis blocking the meridians type cerebral infarction.Methods Forty-five patients with phlegm and blood stasis obstructing the meridians type cerebral infarction admitted to the Neurology Department of our hospital from January 2024 to April 2025 were selected and randomly divided into an observation group of 22 cases and a control group of 23 cases. The observation group was treated with Hua Tuo Zaozao Pills combined with butylphthalide, and the control group was treated with butylphthalide.The treatment courses of both groups were one month.Compare the differences in NIHSS scores, AIP values and BI scores before and after treatment between the two groups.Results One month after treatment, the NIHSS scores and AIP values of both groups were significantly lower than those before treatment (P<0.01), and the NIHSS scores and AIP values of the observation group were significantly lower than those of the control group (P<0.05).The BI scores of the two groups of patients increased significantly compared with those before treatment (P<0.01).Conclusion Huatuo Zaizao Pills combined with butylphthalide can effectively inhibit the progression of atherosclerosis and improve neurological deficits. |
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