| “气化失常”视域下的慢性阻塞性肺病免疫微环境失衡与中医药调治规律探讨 |
| Exploring the Immune Microenvironment Imbalance and the Regulatory Mechanisms of Traditional Chinese Medicine in Chronic Obstructive Pulmonary Disease from the Perspective of “Disorder of Qi Transformation”Wang Huifang , Hou Chaofeng , Sun Weixu* |
| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 气化失常 免疫稳态 中医药 |
| 英文关键词: chronic obstructive pulmonary disease abnormal gasification immune homeostasis Traditional Chinese Medicine |
| 基金项目:河南省中医药传承与创新人才工程(仲景工程)中医药拔尖人才(豫卫中医函〔2021〕15号)；国家中医药管理局第五批全国中医临床优秀人才研修项目( 国中医药人教函〔2022〕1 号) ；河南省中医药研究专项课题(课题编号:2024ZY2191) |
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| 中文摘要: |
| 文章基于“气化失常”理论,探讨慢性阻塞性肺疾病(COPD)免疫微环境异常的病机特征及中医药干预规律。认为本病虽发于肺,实系肺、脾、肾三脏气机升降出入失度,致清阳不升、浊阴不降、痰瘀互结、卫外不固,形成气化障碍与免疫稳态破坏的统一病理。气化失常反映机体能量代谢与免疫反应的系统失衡,其演变贯穿疾病发生、迁延与复发全过程。中医药以“复其气化”为治,通过理气调中、健脾运湿、宣肺肃降、活血通络等多维干预,重建气机升降出入之序,恢复阴阳协调与免疫自稳。气化调衡体现中医整体性、双向性与动态性调控特征,其理论内涵与现代系统生物学多维耦合与自调稳态理念相契合,为中医药防治慢性气道炎症性疾病提供了新的系统思路与理论依据。 |
| 英文摘要: |
| Grounded in the "Qi-harmonization dysfunction" theory, this study investigates the pathophysiological mechanisms and TCM intervention patterns of immune microenvironment abnormalities in chronic obstructive pulmonary disease (COPD). The research posits that while COPD originates in the lungs, its root lies in the imbalance of qi circulation among the three vital organs (lungs, spleen, and kidneys). This dysfunction disrupts the ascending and descending flow of clear yang and turbid yin, leads to phlegm-stasis accumulation, and compromises the body"s defensive qi, ultimately forming a unified pathological process characterized by qi-harmonization disorders and immune homeostasis disruption. The qi-harmonization dysfunction reflects systemic imbalance in energy metabolism and immune response, persisting throughout disease progression, exacerbation, and recurrence. TCM addresses this through "restoring qi-harmonization" via multi-dimensional interventions including qi regulation, spleen-strengthening, dampness elimination, lung-promotion, and blood circulation enhancement. These approaches aim to restore the proper flow of qi and achieve yin-yang balance and immune self-regulation. The qi-harmonization regulation embodies TCM"s holistic, bidirectional, and dynamic therapeutic principles, which align with modern systems biology concepts of multidimensional coupling and self-regulating homeostasis. This integration provides novel systematic frameworks and theoretical foundations for TCM management of chronic airway inflammatory diseases. |
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