文章摘要
膜性肾病的中西医研究进展与展望
Research Progress and Prospect of traditional Chinese and Western Medicine on membranous Nephropathy
投稿时间:2020-10-01  修订日期:2020-10-19
DOI:
中文关键词: 膜性肾病,正虚邪实,补体系统,免疫抑制剂,参芪地黄汤
英文关键词: membranous nephropathy, deficiency and excess, complement system, immunosuppressant, Shenqi Dihuang Decoction
基金项目:山东中医药科技发展计划(项目编号2019-0180)
作者单位邮编
张雅婷 山东中医药大学 250014
胡洪贞 山东中医药大学附属医院 
母慧娟 山东中医药大学附属医院 
李伟 山东中医药大学附属医院 250014
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中文摘要:
      膜性肾病(membranous nephropathy,MN)是一种目前较为常见的由免疫复合物沉积导致的肾小球疾病,临床上以肾病综合征或无症状蛋白尿为主要表现,发病机制为肾小球足细胞膜的M型磷脂酶A2受体(PLA2R)形成的免疫复合物与足细胞表面自身抗原相结合,进一步激活补体反应,使肾小球滤过屏障出现问题。中医医家提出“正虚邪实”的基本病机,并结合临床经验提出“脾肾亏虚为本,血瘀、湿热为标”的病机。本文针对膜性肾病的病因病机及目前的中西医治疗进展状况进行总结与展望。
英文摘要:
      Membranous nephropathy (Mn) is a common glomerular disease caused by immune complex deposition, which is characterized by nephrotic syndrome or asymptomatic proteinuria in clinic. The immune complex formed by M-type phospholipase A2 receptor (PLA2R) in glomerular podocyte membrane combines with the autoantigen on the surface of podocyte, which further activates complement reaction and causes problems in glomerular filtration barrier. Traditional Chinese medicine doctors put forward the basic pathogenesis of "right vacuity and evil repletion", and combined with clinical experience, put forward the pathogenesis of "deficiency of spleen and kidney as the foundation, blood stasis and damp heat as the standard". This article summarizes and looks forward to the etiology and pathogenesis of membranous nephropathy and the current progress of Chinese and Western medicine treatment.
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