文章摘要
维生素D3联合摄精消白胶囊对早期糖尿病肾病尿蛋白及骨密度的影响
Effect of vitamin D3 combined with shejingxiaobai capsule on urinary protein and bone mineral density in early type 2 diabetic nephropathy
投稿时间:2020-10-21  修订日期:2020-10-28
DOI:
中文关键词: 维生素D3  摄精消白胶囊  糖尿病肾病  尿蛋白  骨密度
英文关键词: 
基金项目:江苏省苏州市科技计划项目(SYSD2017183)
作者单位邮编
王春花 常熟市中医院 215500
周晓春 常熟市中医院 215500
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中文摘要:
      目的 观察维生素D3联合摄精消白胶囊对早期糖尿病肾病患者尿蛋白及骨密度的影响。方法 选取血糖、血压稳定的早期2型糖尿病肾病患者94例,年龄36-73岁,随机分为对照组29例、维生素D3组33例、联合治疗组32例。对照组予以控制血糖、血压、血脂等基本治疗;维生素D3组在对照组的基础上加用口服骨化三醇,每日一次,每次0.25ug;联合治疗组在维生素D3组的基础上加用口服摄精消白胶囊,每日三次,每次三粒。三组均连续治疗三个月。结果 1.与治疗前相比,维生素D3组及联合治疗组治疗后尿总蛋白、尿微量白蛋白均明显下降(P<0.01),骨密度较治疗前明显升高(P<0.01)。2.和对照组比较,维生素D3组患者24h尿总蛋白、尿微量白蛋白明显降低(P<0.05),联合治疗组下降更为明显( P<0.01),维生素D3组及联合治疗组骨密度均明显升高(P<0.05)。结论 维生素D3能升高早期2型糖尿病肾病患者骨密度水平;维生素D3与摄精消白胶囊均能显著降低早期2型糖尿病肾病患者尿蛋白水平,二者联合应用疗效更显著。
英文摘要:
      【 abstract 】 Objective To observe the effect of vitamin D3 combined with shejingxiaobai capsule on urinary protein and bone mineral density in patients with early type 2 diabetic nephropathy.Methods We selected 94 patients with early type 2 diabetic nephropathy, whose blood pressure and blood glucose were stable, aged 36-73 years, including 58 males and 36 females.The patients were randomly divided into control group (29 cases), vitamin D3 group (33 cases) and combined treatment group (32 cases). All patients were given routine treatment such as hypoglycemia and hypotensive.On this basis,the vitamin D3 group was given vitamin D3 0.25ug,qd,po ,for 3 months;and the combined treatment group was given vitamin D3 combined with shejingxiaobai 3 capsules,tid,po,for 3 months.Results 1. Compared with before treatment, total urinary protein and urinary microalbumin in the vitamin D3 group and the combined treatment group were significantly decreased after treatment (P<0.01), and the bone mineral density was significantly increased (P<0.01).2 .Compared with the control group, the total urinary protein and urinary microalbumin in the vitamin D3 group were significantly reduced (P<0.05), the decrease was more obvious in the combined treatment group (P< 0.01), and the bone mineral density was
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