文章摘要
上皮间质转化与非小细胞肺癌治疗耐药及中医药干预策略
Epithelial-mesenchymal Transition and drug resistance in the treatment of Non-Small Cell Lung Cancer and intervention Strategy of Traditional Chinese Medicine
投稿时间:2020-12-28  修订日期:2020-12-28
DOI:
中文关键词: 上皮间质转化  非小细胞肺癌  耐药  中医药
英文关键词: Epithelial-mesenchymal transition(EMT)  non-small cell lung cancer(NSCLC)  drug resistance  Traditional Chinese Medicine.
基金项目:上海市教育委员会科研创新计划重大项目(NO:2017-01-07-00-10-E00064);上海市中医药领军人才培养计划[NO:ZY(2018-2020)-RCPY-1001];龙华医院科技创新项目(NO.CX202011)
作者单位邮编
夏尽力 上海中医药大学附属龙华医院肿瘤二科 200032
邓海滨 上海中医药大学附属龙华医院肿瘤二科 200032
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中文摘要:
      摘要: 上皮间质转化(EMT)是上皮细胞获得间充质表型的基本形态发生过程,其在肿瘤的侵袭、转移和耐药中起到重要的作用。近年来,EMT在非小细胞肺癌(NSCLC)耐药中的作用已得到越来越多的认识,许多EMT相关的信号通路、转录因子都被证实参与了NSCLC治疗耐药,靶向EMT也被认为是克服耐药的新机会。中医药在干预EMT引起的NSCLC耐药中扮演了重要的角色,配合现代医药使用,可以增强免疫力、减少毒副作用、逆转EMT引起的肿瘤耐药等,从而起到增效减毒的作用。本文主要对EMT引起NSCLC治疗耐药机制及中医药干预EMT引起的NSCLC治疗耐药策略进行概述。
英文摘要:
      Abstract:Epithelial-mesenchymal Transition (EMT) is the basic morphogenesis process for epithelial cells to acquire mesenchymal phenotype, which plays an important role in tumor invasion, metastasis and drug resistance. In recent years, The role of EMT in NSCLC drug resistance has been more and more recognized. Many EMT-related signaling pathways and transcription factors have been confirmed to be involved in NSCLC treatment drug resistance. Targeting EMT is also considered as a new opportunity to overcome drug resistance. Traditional Chinese medicine plays an important role in the intervention of NSCLC drug resistance caused by EMT. With the use of modern medicine, it can enhance immunity, reduce side effects, reverse tumor drug resistance caused by EMT, and play a synergistic role. This article mainly summarizes the mechanism of drug resistance induced by EMT in NSCLC and the strategy of traditional Chinese medicine in the treatment of NSCLC caused by EMT.
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