文章摘要
基于真实世界研究的新型冠状病毒肺炎中药介入时机探讨
投稿时间:2020-12-28  修订日期:2021-03-27
DOI:
中文关键词: 新型冠状病毒肺炎  中药介入时机  真实世界研究
英文关键词: COVID-19  Traditional Chinese Medicine  Real world study
基金项目:山东省重大科技创新工程(2020SFXGY04-1),泰山学者建设工程(201712096)。
作者单位邮编
朱雪 山东中医药大学附属医院 250011
胡渊龙 山东中医药大学 
沈宁 山东中医药大学附属医院 
贾新华 山东中医药大学附属医院 
张兴彩 山东中医药大学附属医院 
韩健 山东中医药大学附属医院 
岳淼 山东省胸科医院 
袁成民 济南市传染病医院 
邱占军 山东中医药大学附属医院 
李慧 山东中医药大学附属医院 
张伟 山东中医药大学附属医院 250011
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中文摘要:
      目的:基于真实世界研究探讨在新型冠状病毒肺炎中医药治疗的介入时机对病程、住院时间、核酸转阴时间的影响。方法:采用真实世界研究的方法,回顾性分析来自山东与湖北定点医院已出院的新型冠状病毒肺炎患者,在未调整混杂变量和调整混杂变量的情况下,分析中药介入推迟时间对病程时间的影响。结果:在未调整混杂情况下,中药介入推迟时间与病程时间为正相关关系(β=0.67,95%CI=0.57 to 0.76, p<0.001),同时又发现中药介入推迟时间与住院时间(β=0.18,95%CI=0.08 to 0.28,p<0.001)、中药介入推迟时间与转阴时间(β=0.44,95%CI=0.34 to 0.53,p<0.001)均为正相关关系。在调整年龄和性别的情况下,中药介入推迟时间与病程时间依然为正相关关系(β=0.65,95%CI=0.60 to 0.80,p<0.001)。分层分析表明各亚组中中药介入推迟时间与病程时间均正相关关系。结论:中药介入延迟是病程延长的危险因素,中药早期介入能够能够缩短患者的核酸转阴时间、病程和住院时间。因此在此类公共卫生事件中,中医药应尽早介入,使患者得到更大获益。
英文摘要:
      Objective: To explore the timing of intervention in the treatment of traditional Chinese medicine in COVID-19 based on real-world research. Methods: Using the method of real-world study, retrospective analysis of COVID-19 patients who have been discharged from designated hospitals in Shandong and Hubei, without adjusting confounding variables and adjusting confounding variables, to analyze the effect of traditional Chinese medicine intervention delay time on the course of disease.Results: Without adjusting the confusion, there was a positive correlation between the postponement time of traditional Chinese medicine intervention and the course of disease (β = 0.67, 95%CI=0.57 to 0.76, p<0.001). At the same time, it was found that there was a positive correlation between the postponement time of traditional Chinese medicine intervention and the time of hospitalization (β = 0.18, 95%CI=0.08 to 0.28, p<0.001), and between the postponement time of traditional Chinese medicine intervention and the time of turning negative (β = 0.44, 95% CI=0.34 to 0.53, p<0.001). Under the condition of adjusting age and sex, the delay time of traditional Chinese medicine intervention was still positively correlated with the course of disease (β = 0.65, 95%CI=0.60 to 0.80, p<0.001). Stratified analysis showed that there was a positive correlation between the postponement time of traditional Chinese medicine intervention and the course of disease in each subgroup. Conclusion: Delayed intervention of traditional Chinese medicine is a risk factor for prolonging the course of disease. the earlier the time of early intervention of traditional Chinese medicine, the faster the nucleic acid negative conversion of patients, and can shorten the time of nucleic acid negative conversion, the course of disease and the time of hospitalization. Therefore, in such public health events, traditional Chinese medicine should be intervened as soon as possible to benefit patients more
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