| 【Abstract】Objective To observe the clinical effect of compound Siyadan hair growth tincture combined with Aesculus turmeric liniment in the treatment of seborrheic alopecia due to spleen deficiency and dampness. Methods 120 male patients with seborrheic alopecia due to spleen deficiency and dampness accumulation were randomly divided into groups A, B and C, with 40 cases in each group. The mode of administration is: A is the external use of compound Siartan hair growth tincture and Aesculus turmeric liniment combined with oral Chinese medicine treatment, group B is oral Chinese medicine, and group C is oral finasteride plus external minoxidil tincture. Observe the scores of various symptoms and signs (greasy, dander, itching, hair loss, hair growth) of each group before and after treatment, and compare the clinical efficacy, adverse reactions, recurrence rate, and overall satisfaction of each group. Results The symptoms and signs scores of the three groups after treatment were compared with those before treatment in the same group. The difference was statistically significant (p <0.05); the "changes in symptoms and signs after treatment" and "comparison of efficacy" of group A were better than those of group B, and had Statistical significance (P <0.05); there was no significant difference between "adverse reactions" and "recurrence rate" (P> 0.05). The comparison of "changes in symptoms and signs after treatment" between groups A and C showed that greasiness and itching were better than group C (P <0.05), while the other three items (hair loss, dandruff and hair growth) had no significant difference (P> 0.05) There was no significant difference in "comparison of efficacy" (P>0.05); the "adverse reactions" and "recurrence rate" of group C were higher than those of group A, which were statistically significant (p <0.05). The satisfaction of group A was higher than that of groups B and C, which was statistically significant (p <0.05). Conclusion In the treatment of seborrheic alopecia due to spleen deficiency and dampness accumulation, the compound Siyadan hair growth tincture combined with Aesculus turmeric liniment has obvious therapeutic effect and safety.