文章摘要
四物汤通过调节血清激素水平改善多囊卵巢综合征大鼠卵巢功能
Siwu Tang improves ovarian function in rats with polycystic ovary syndrome by regulating serum hormone levels
投稿时间:2021-02-04  修订日期:2021-02-07
DOI:
中文关键词: 四物汤  多囊卵巢综合征  来曲唑  血清激素  卵巢功能
英文关键词: Siwu Tang, PCOS, Letrozole, Serum Hormones, Ovarian Function
基金项目:81803913
作者单位邮编
朱彤 华中科技大学同济医学院附属同济医院 430030
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中文摘要:
      目的 探讨四物汤治疗多囊卵巢综合征 (PCOS) 大鼠的起效机制。 方法 选取湖北省疾控中心提供的6-8周龄wistar SPF级雌性大鼠25只, 用来曲唑诱导建立PCOS大鼠动物模型, 将25只大鼠随机分为正常组、模型组、中药低、高剂量组和二甲双胍组,记录PCOS大鼠的动情周期,观察卵巢形态, 检测血清激素水平。 结果 物汤干预后PCOS大鼠动情期天数增加,动情间期天数减少;卵巢囊肿数降低、黄体数增加。大鼠血清黄体生成素、睾酮水平和黄体生成素与卵泡刺激素比值降低, 卵泡刺激素、雌二醇水平升高。 结论 物汤通过纠正血清激素水平,改善PCOS大鼠卵巢功能。 关键词:四物汤;多囊卵巢综合征;来曲唑;血清激素;卵巢功能
英文摘要:
      Objective To explore the mechanism of Siwu Tang in the treatment of polycystic ovary syndrome rats. Methods 25 female wistar rats (6-8 week old) provided by Hubei Provincial Center for Disease Control and Prevention were used to induce the establishment of a PCOS animal model with letrozole. The rats were randomly divided into normal, model, SWT1, SWT2 and Met groups, and the estrus cycle, ovarian morphology and levels of serum hormone of PCOS rats were recorded. Results After the treatment of Siwu Tang, the number of estrus days in PCOS rats were increased while the diestrus days were decreased,and the number of ovarian cysts decreased and while corpus luteum increased. In addition, the levels of rat serum luteinizing hormone and testosterone and the ratio of luteinizing hormone to follicle stimulating hormone were decreased, and the levels of follicle stimulating hormone and estradiol were increased.
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