文章摘要
降颅压西药联合菖蒲郁金汤治疗小儿重症病毒性脑炎的临床观察
Clinical observation on western medicine for intracranial pressure lowering combined with Changpu Yujin decoction in the treatment of severe viral encephalitis in children
投稿时间:2021-02-19  修订日期:2021-02-19
DOI:
中文关键词: 病毒性脑炎  重症  菖蒲郁金汤  甘露醇
英文关键词: Viral encephalitis  Severe  Changpu Yujin decoction  Mannitol
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作者单位邮编
高亮 驻马店市中心医院 463000
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中文摘要:
      目的 观察降颅压西药联合菖蒲郁金汤治疗小儿重症病毒性脑炎(VME)的临床疗效。方法 选取我院收治的65例重症VME患儿为研究对象,随机分为观察组(n=32)与对照组(n=33),对照组患儿予常规降颅压治疗,观察组患儿在降颅压基础上联合菖蒲郁金汤治疗。比较治疗前及治疗7d后两组中医症状积分,脑脊液中枢神经特异(S100-β)蛋白、神经元特异性烯醇化酶(NSE)水平,治疗期间两组主要症状、体征消失时间。结果 治疗7d后,两组发热、神昏、头晕、纳呆中医症状积分及脑脊液中S100-β蛋白、NSE水平均较治疗前明显降低,且观察组明显低于同一时间对照组(P<0.05);观察组神志障碍、抽搐、呕吐、肌力下降消失时间均明显少于对照组(P<0.05)。结论 降颅压西药联合菖蒲郁金汤可迅速改善患儿主要临床症状,减少脑损伤,适宜广泛应用于临床。
英文摘要:
      Objective To observe the clinical efficacy of western medicine for intracranial pressure lowering combined with Changpu Yujin decoction in the treatment of severe viral encephalitis (VME) in children. Methods 65 children patients with severe VME admitted to our hospital were selected as the research subjects, and they were randomly divided into observation group (n=32) and control group (n=33). Control group received conventional intracranial pressure lowering therapy, and observation group was combined with Changpu Yujin decoction on the basis of intracranial pressure lowering. The scores of TCM symptoms and levels of cerebrospinal fluid central nervous system specific protein (S100-β) and neuron-specific enolase (NSE) before treatment and after 7d of treatment and the disappearance times of main symptoms and signs during treatment were compared between the two groups. Results After 7d of treatment, the scores of TCM symptoms of fever, coma, dizziness and anorexia and levels of cerebrospinal fluid S100-β protein and NSE in the two groups were significantly lower than those before treatment, and the scores and levels in observation group were significantly lower than those in control group at the same time point (P<0.05). The disappearance times of mental disorder, convulsions, vomiting and muscle strength decrease in observation group were significantly shorter than those in control group (P<0.05). Conclusion Western medicine for intracranial pressure lowering combined with Changpu Yujin decoction can quickly improve the main clinical symptoms and reduce the cerebral injury, and it is suitable for wide application in clinical practice.
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