文章摘要
滋阴止眩汤联合氟桂利嗪治疗阴虚阳亢型前庭性偏头痛的临床观察
Clinical Observation of Ziyin Zhixuan Decoction Combined with Flunarizine in Treatment of Vestibular Migraine of Yin Deficiency and Yang Hyperactivity Type
投稿时间:2021-02-24  修订日期:2021-02-24
DOI:
中文关键词: 滋阴止眩汤  前庭性偏头痛  阴虚阳亢  中医证候积分
英文关键词: Ziyin zhixuan decoction  vestibular migraine  Yin deficiency and yang hyperactivity  Traditional Chinese Medicine syndrome score
基金项目:
作者单位邮编
陈清 湖北省中西医结合医院 430015
张肖 湖北省中西医结合医院 430015
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中文摘要:
      目的 探讨滋阴止眩汤联合氟桂利嗪治疗阴虚阳亢型前庭性偏头痛(vestibular migraine, VM)患者的临床疗效和安全性。方法 选取84例阴虚阳亢型VM患者,按照随机数字表法分为观察组及对照组,每组42例。其中对照组口服盐酸氟桂利嗪胶囊治疗,治疗组在对照组的基础上加用滋阴止眩汤治疗。连续治疗4周后,比较2组中医证候积分、眩晕障碍量表(dizziness handicap inventory,DHI)评分、医院用焦虑抑郁量表(hospital anxiety and depression scale,HADS)评分以及不良事件发生情况。结果 治疗后4周,观察组患者中医证候积分、DHI评分、HADS评分明显低于对照组(P<0.05),总有效率明显高于对照组(P<0.05),2组不良事件发生率均较低,不良反应症状轻微。结论 滋阴止眩汤联合氟桂利嗪治疗阴虚阳亢型VM患者,可有效缓解患者的焦虑抑郁情绪状态,提高临床疗效,改善患者生活质量,且不良反应轻微,值得推广。
英文摘要:
      Objective To explore the clinical efficacy and safety of Ziyin Zhixuan decoction combined with flunarizine in treatment of vestibular migraine (VM) patients with yin deficiency and yang hyperactivity. Methods 84 patients with VM of yin deficiency and yang hyperactivity type were randomly divided into observation group and control group, 42 cases in each group. The control group was treated with flunarizine hydrochloride capsules, and the treatment group was treated with Ziyin Zhixuan Decoction on the basis of the control group. After 4 weeks of continuous treatment, the scores of Traditional Chinese Medicine(TCM) syndromes, dizziness handicap inventory (DHI) scores, hospital anxiety and depression scale (HADS) scores, and adverse events were compared between the two groups. Result After 4 weeks of treatment, the TCM syndrome score, DHI score and HADS score of the observation group were significantly lower than those of the control group (P<0.05), and the total effective rate was significantly higher than that of the control group (P<0.05). The incidence of adverse events was lower in both groups, and the symptoms of adverse reactions were mild. Conclusion Ziyin Zhixuan decoction combined with flunarizine in treatment of VM patients with Yin deficiency and yang hyperactivity can effectively relieve the anxiety and depression of patients, improve the clinical efficacy, improve the quality of patients’ life , and the adverse reactions are mild, which is worthy of promotion.
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