文章摘要
参芪益肺汤联合免疫治疗对晚期NSCLC患者免疫功能和生命质量的影响
Effect of Shenqi Yifei Decoction combined with immunotherapy on immune function and quality of life in patients with advanced NSCLC
投稿时间:2021-03-05  修订日期:2021-04-25
DOI:
中文关键词: 参芪益肺汤  免疫治疗  非小细胞肺癌  免疫功能  生命质量
英文关键词: Shenqi Yifei Decoction  Immunotherapy  Non-Small Cell Lung Cancer  Immune Function  Quality of Life
基金项目:
作者单位邮编
王学语 山东中医药大学 济南 250000
孙金芳 山东省青岛市第五人民医院 青岛 266000
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中文摘要:
      目的 观察参芪益肺汤联合免疫治疗对晚期NSCLC患者免疫功能和生命质量的影响。方法 选择晚期非小细胞肺癌患者55例,随机分为两组。对照组使用免疫治疗,试验组加用参芪益肺汤,治疗4周期后评价疗效。结果 治疗后试验组中医证候评分总分及神疲乏力、气短懒言、口干咽燥的评分相比治疗前下降,而对照组仅有神疲乏力评分较前降低,且试验组证候改善率高于对照组。试验组患者在PACT-L量表中各领域评分以总分相比治疗前均显著提高;而对照组在PWB领域、EWB领域、LCS领域评分及总分相比治疗前也有增加;但试验组提升程度高于对照组。治疗后两组患者CD3+、CD4+水平均较治疗前提高;但试验组CD3+、CD4+提高的水平高于对照组;试验组CD4+/CD8+比值较对照组提升显著。两组患者KPS评分治疗前后均无明显变化。治疗后试验组CEA、CYFRA21-1水平相比治疗前明显下降,而对照组肿瘤标志物水平无明显变化。结论 参芪益肺汤联合免疫治疗能改善患者的气阴两虚症状,提髙生命质量,增强免疫功能,改善患者预后。
英文摘要:
      Objective To observe the effect of Shenqi Yifei Decoction combined with immunotherapy on the immune function and quality of life of patients with advanced NSCLC. Methods Fifty-five patients with advanced non-small cell lung cancer with deficiency of both qi and yin were selected and randomly divided into two groups. The experimental group used Shenqi Yifei Decoction combined with immune drugs, and the control group used immune single drugs. The efficacy was evaluated after 4 cycles of treatment. Results After treatment, the total score of TCM syndrome scores in the test group and the scores of Shenpi fatigue, shortness of breath, lazy speech, dry mouth and throat decreased compared with before treatment, while the control group only had Shenpi fatigue score lower than before, and the test group's syndromes The improvement rate is higher than that of the control group. In the PACT-L scale, the scores of the patients in the test group in the PWB, SWB, EWB, FWB, and LCS areas were significantly improved compared with the total scores before the treatment; while the control group was in the PWB, EWB, and LCS areas. The total score also increased compared with that before treatment; but the test group's scores in the PWB, FWB, and LCS fields and the overall score improvement were higher than those of the control group. After treatment, the levels of CD3+ and CD4+ in the two groups were higher than before treatment; but the levels of CD3+ and CD4+ in the test group were higher than those in the control group; the ratio of CD4+/CD8+ in the test group was significantly higher than that before treatment, while the control group had no significant change. There was no significant change in the KPS scores of the two groups of patients before and after treatment. After treatment, the levels of CEA, CYFRA21-1 in the experimental group were significantly lower than before treatment, while the levels of CEA, CYFRA21-1 and CA125 in the control group did not change significantly before and after treatment. Conclusion Shenqi Yifei Decoction combined with immunotherapy can improve the symptoms of deficiency of both Qi and Yin, improve the quality of life, enhance immune function, reduce the level of tumor markers, and improve the prognosis of patients.
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