文章摘要
复方红景参丸治疗慢性阻塞性肺疾病的临床效果研究
Clinical effect of Compound red ginseng Pill on chronic obstructive pulmonary disease
投稿时间:2021-03-07  修订日期:2021-03-10
DOI:
中文关键词: 复方红景参丸  慢性阻塞性肺疾病  肺功能  炎症因子
英文关键词: Compound red ginseng pill  Chronic obstructive pulmonary disease  Lung function  Inflammatory cytokines
基金项目:四川省中医药管理局项目(NO. 2017C012)
作者单位邮编
李修元 西南医科大学附属中医医院呼吸内科 四川 泸州 646000
张馨月 西南医科大学附属中医医院中西医结合学院 四川 泸州 
曾锐 西南医科大学附属中医医院中西医结合学院 四川 泸州 
孙琴 西南医科大学附属中医医院中西医结合药物研究中心 四川 泸州 646000
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中文摘要:
      目的 探讨复方红景参丸治疗慢性阻塞性肺疾病的临床效果。方法 选取我院2020年7月-2020年8月门诊或经住院治疗后好转出院当天的慢性阻塞性肺疾病患者60例,采用随机数字表法分为对照组(30例) 和观察组(30例)。对照组给予规律吸入信必可,观察组在对照组治疗基础上,每天给予复方红景参丸口服。对两组患者治疗前后进行慢阻肺评估测试(CAT)、中医症状积分和肺部啰音消失时间评估,并进行肺功能检测、血气分析和炎性指标检测,记录28天内慢阻肺急性加重频次。结果 两组患者治疗前CAT积分、中医症状积分、肺部啰音积分、FEV1、FEV1/FVC、PaO2 、PaCO2、WBC、N和CRP 水平均无显著差异(P>0.05);治疗后,两组CAT积分、中医症状积分、肺部啰音积分、PaCO2、WBC、N和CRP 水平均降低,FEV1、FEV1/FVC和PaO2水平均升高,差异均有统计学意义(P<0.05)。且观察组CAT积分、中医症状积分、PaCO2 、WBC和CRP低于对照组,观察组FEV1、FEV1/FVC、PaO2高于对照组,差异均有统计学意义(P<0.05)。结论 复方红景参丸辅助治疗慢阻肺可显著控制疾病进展和临床症状,有效改善患者呼吸功能,降低机体炎症水平和慢阻肺急性加重频次。具有良好的临床推广价值。
英文摘要:
      Objective To investigate the effect of compound red ginseng pills on chronic obstructive pulmonary disease (COPD). Methods Sixty patients with chronic obstructive pulmonary disease (COPD) discharge from our hospital from July 2020 to August 2020 after outpatient or inpatient treatment were randomly divided into control group (n = 30) and observation group (n = 30). The control group was given regular inhalation of Symbicort, and the observation group was given compound red ginseng pill orally every day on the basis of treatment in the control group. COPD assessment test, TCM symptom score and pulmonary rales disappear time were evaluated for the two groups of patients, and pulmonary function tests, blood gas analysis and inflammatory indicators were performed, before and after treatment. The frequency of acute exacerbation of chronic obstructive pulmonary disease was recorded after the treatment. Results There was no significant difference in CAT score, TCM symptom score, pulmonary rales score, FEV1, FEV1/FVC, PaO2, PaCO2, WBC, N and CRP levels before treatment between the two groups (P>0.05); CAT score, TCM symptom score, pulmonary rales score, PaCO2, WBC, N and CRP levels were decreased, FEV1, FEV1/FVC and PaO2 levels were increased in the two groups, and the differences were statistically significant after the treatment (P<0.05). And CAT score, TCM symptom score, PaCO2, WBC and CRP in the observation group were lower than those in the control group, FEV1, FEV1/FVC, and PaO2 in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). Conclusion Compound red ginseng Pills can significantly control the progression and clinical symptoms of chronic obstructive pulmonary disease, effectively improve the respiratory function, and reduce the level of inflammation and the frequency of acute exacerbation of chronic obstructive pulmonary disease. This has good value of clinical promotion.
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