文章摘要
温阳愈溃汤治疗脾胃虚寒型幽门螺杆菌感染性胃溃疡的临床研究
Study on Clinical Efficacy and Mechanism of Wenyang Yukui Decoction in Treating Spleen-Stomach Deficiency-cold Helicobacter Pylori Infectious Gastric Ulcer
投稿时间:2021-03-20  修订日期:2021-03-25
DOI:
中文关键词: 胃溃疡  温阳愈溃汤  炎症因子  溃疡因子
英文关键词: Gastric ulcer  Wenyang Yukui Decoction  Inflammatory factor  Ulcer factor
基金项目:1.河南省中医药科学研究专项课题(课题编号:2019ZY3043).2.河南省首届青苗人才计划项目。
作者单位邮编
余二伟 驻马店市中医院 463000
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中文摘要:
      目的 观察温阳愈溃汤治疗脾胃虚寒型幽门螺杆菌感染性胃溃疡的临床疗效和作用机制。方法 100例脾胃虚寒型幽门螺杆菌感染性胃溃疡患者按照随机数字表法分为观察组和对照组各50例。对照组采用四联疗法治疗,观察组在对照组基础上采用温阳愈溃汤治疗;治疗前后观察患者胃镜下溃疡变化情况(溃疡直径、底部厚苔面积、再生上皮面积和溃疡周围黏膜充血面积);检测患者血清IL–6、IFN-γ、CRP等炎症因子水平,检测患者胃黏膜EGF、EGFR等溃疡相关因子水平;根据胃镜检查情况进行临床疗效评价。结果 治疗后,观察组患者溃疡直径、底部厚苔面积、溃疡周围黏膜充血面积较治疗前明显变小,且小于对照组(P均<0.05),再生上皮面积大于治疗前和对照组(P均<0.05);观察组患者胃黏膜EGF、EGFR水平明显降低且低于对照组(P均<0.05);观察组患者血清IL–6、IFN-γ、CRP水平明显降低,且低于对照组,差异均具有统计学意义(P均<0.05);观察组临床总有效率98.00%明显大于对照组临床总有效率84.00(P<0.05);观察组HP根除率100.00%明显大于对照组HP根除率84.00%(P<0.05)。结论 采用温阳愈溃汤辅助四联疗法治疗脾胃虚寒型幽门螺杆菌感染性胃溃疡,能够明显促进溃疡愈合,提高治愈率,这儿可能与其调节血清炎症因子水平,改善溃疡相关因子有关。
英文摘要:
      Objective To observe the clinical efficacy and mechanism of Wenyang Yukui Decoction in the treatment of gastric ulcer caused by Helicobacter pylori with spleen and stomach deficiency and cold. Methods 100 cases of Helicobacter pylori infective gastric ulcer patients with spleen-stomach deficiency-cold type were divided into observation group and control group with 50 cases each according to random number table. The control group was treated with quadruple therapy, and the observation group was treated with Wenyang Yukui Decoction on the basis of the control group; before and after treatment, the gastroscopic ulcer changes (diameter of ulcer, area of thick moss at the bottom, area of regenerated epithelium, and area of mucosal hyperemia around the ulcer) were observed before and after treatment. ); Detect the levels of serum IL-6, IFN-γ, CRP and other inflammatory factors in patients, and detect the levels of ulcer-related factors such as EGF and EGFR in the gastric mucosa; evaluate the clinical efficacy according to the gastroscopy. Results After treatment, the diameter of the ulcer, the area of thick moss at the bottom, and the area of hyperemia around the ulcer in the observation group were significantly smaller than those before treatment, and were smaller than those of the control group (P<0.05), and the area of regenerated epithelium was larger than that before treatment and the control group (P
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