| 粪菌移植治疗肝衰竭的研究进展[*] |
| Advances in fecal microbiota transplantation for liver failure |
| DOI： |
| 中文关键词: 粪菌移植 肝衰竭 肠道菌群 肠肝轴 |
| 英文关键词: |
| 基金项目:国家自然科学基金(No:82160837),第五批全国中医临床优秀人才研修项目(国中医药人教函〔2022〕1号),2019年中医药传承与创新人才培养平台建设项目(国中医药人教函〔2019〕41号),广西中医药适宜技术开发与推广项目(No.GZSY21-29),广西中医药大学岐黄工程高层次人才团队培育项目(No.2021007) |
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| 中文摘要: |
| 肝功能衰竭（Liver failure）病情凶险，并发症较多，而且病死率高，预后极差。近年来许多文献资料表明肝衰竭患者存在不同程度的肠道菌群失调，而粪菌移植(Fecal microbiota transplantation，FMT)作为一种有效的重建患者整体肠道菌群的治疗方法，显示出了对LF的潜在治疗效果。本文就肠道菌群与肝衰竭的关系以及FMT治疗LF的基础和临床研究进行综述，为肝衰竭的临床诊疗提供新的方向和理论依据。 |
| 英文摘要: |
| ABSTRACT Liver failure is a dangerous disease with many complications, high mortality and poor prognosis. In recent years, many literatures have shown that patients with liver failure have different degrees of intestinal flora imbalance, and fecal microbiota transplantation, as an effective treatment method to reconstruct the overall intestinal flora of patients, has shown a potential therapeutic effect on LF. This article reviews the relationship between intestinal flora and liver failure and the basic and clinical research of FMT in the treatment of LF, so as to provide a new direction and theoretical basis for the clinical diagnosis and treatment of liver failure. |
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