保妇康栓对HPV感染性宫颈炎患者Gata-3水平及LCT结果影响

赵海瑞

文章摘要

保妇康栓对HPV感染性宫颈炎患者Gata-3水平及LCT结果影响

Effect of Baofukang Suppository on the level of Gata-3 and the results of LCT in patients with HPV-infected cervicitis

DOI：

中文关键词: 保妇康栓干扰素人乳头瘤病毒感染性宫颈炎疗效

英文关键词: Baofukang Suppository Interferon Human papillomavirus infected cervicitis Curative effect

基金项目:

作者	单位	邮编
赵海瑞	郑州市惠济区人民医院妇科	450044

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中文摘要:

目的：观察保妇康栓联合干扰素治疗人乳头瘤病毒（HPV）感染性宫颈炎的疗效及液基薄层细胞学检查（LCT）结果。方法：选择2019年6月-2022年6月医院收治的129例HPV感染性宫颈炎患者，按随机数字表法分3组，A组43例予保妇康栓治疗，B组43例予干扰素治疗，联合组43例予保妇康栓联合干扰素治疗。比较3组的疗效、HPV病毒载量、转阴率、Th1细胞、Th2细胞、Th1/Th2转录因子及LCT、不良反应。结果：联合组的总有效率（97.67%，42/43）高于A组（76.74%，33/43）、B组（79.07%，34/43）（P均<0.05），HPV转阴率（90.70%，39/43）高于A组（67.44%，29/43）、B组（69.77%，30/43）（P均<0.05）。治疗后，3组的Th1、T-bet mRNA均大于治疗前（P均<0.05），HPV病毒载量、Th2、Gata-3 mRNA均小于治疗前（P均<0.05），且联合组的Th1、T-bet mRNA均大于A组、B组（P均<0.05），HPV病毒载量、Th2、Gata-3 mRNA均小于A组、B组（P均<0.05）。治疗后，3组的LCT正常率均高于治疗前（P均<0.05），且联合组的LCT正常率（83.72%，36/43）高于A组（55.81%，24/43）、B组（53.49%，23/43）（P均<0.05）。各组间不良反应总发生率比较差异无显著性（P>0.05）。结论：保妇康栓联合干扰素治疗HPV感染性宫颈炎疗效可靠，提高HPV转阴率，改善LCT检查结果，且未增加不良反应。

英文摘要:

Objective: To observe the efficacy of Baofukang Suppository combined with interferon in the treatment of human papillomavirus (HPV) infected cervicitis and the results of liquid-based thin layer cytology (LCT). Methods: A total of 129 patients with HPV infected cervicitis admitted to the hospital from June 2019 to June 2022 were randomly divided into three groups according to the random number table. 43 patients in group A were treated with Baofukang Suppository, 43 patients in group B were treated with interferon, and 43 patients in the combined group were treated with Baofukang Suppository and interferon. The curative effect, HPV viral load, negative conversion rate, Th1 cells, Th2 cells, Th1/Th2 transcription factors, LCT and adverse reactions of the three groups were compared. Results: The total effective rate of combined group (97.67%, 42/43) was higher than that of group A (76.74%, 33/43) and group B (79.07%, 34/43) (both P<0.05), the negative rate of HPV (90.70%, 39/43) was higher than that of group A (67.44%, 29/43) and group B (69.77%, 30/43) (both P<0.05). After treatment, Th1 and T-bet mRNA in the three groups were higher than those before treatment (P<0.05), HPV viral load, Th2, Gata-3 mRNA were lower than those before treatment (P<0.05), Th1 and T-bet mRNA in combination group were higher than those in group A and group B (P<0.05), HPV viral load, Th2, Gata-3 mRNA were lower than those in group A and group B (P<0.05). After treatment, the normal rate of LCT in the three groups was higher than that before treatment (P<0.05), and the normal rate of LCT in the combined group (83.72%, 36/43) was higher than that in group A (55.81%, 24/43) and group B (53.49%, 23/43) (P<0.05). There was no significant difference in the total incidence of adverse reactions among the groups (P>0.05). Conclusion: Baofukang Suppository combined with interferon in the treatment of HPV infective cervicitis has reliable efficacy, improves the rate of HPV negative conversion, improves the results of LCT, and does not increase adverse reactions

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