基于关联规则和聚类分析探讨膈下逐瘀汤中活血药和行气药用药规律研究

王丽寒; 王锐; 杨婧

文章摘要

基于关联规则和聚类分析探讨膈下逐瘀汤中活血药和行气药用药规律研究

Based on association rules and clustering analysis in the Gexia Zhuyu Decoction Study on the law of blood circulation medicine and qi medicine

DOI：

中文关键词: 膈下逐瘀汤关联规则聚类分析用药规律

英文关键词: Gexia Zhuyu Decoction Association rules Cluster analysis Drug administration rules

基金项目:]中央支持地方高校改革发展优秀青年人才项目(No.2020YQ05)；国家自然科学基金资助项目(81603418)

作者	单位	邮编
王丽寒	黑龙江中医药大学· 哈尔滨	150040
王锐	黑龙江中医药大学
杨婧	黑龙江中医药大学	150040

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中文摘要:

目的系统整理并归纳总结膈下逐瘀汤临床组方用药规律，分析膈下逐瘀汤中诸药在活血和行气功效上的组方原则，探究王清任气血理论的临床和药学研究依据，建立膈下逐瘀汤组方气血拆方的理论依据，为同类经方拆方研究提供参考。方法在中国知网（CNKI），万方数据库（Wan Fang），维普（VIP）等数据库中检索自2012年至2022年所有关于膈下逐瘀汤应用的相关文献，提取方剂名称、药物组成、药物功效、药物类别，利用SPSS Modeler18.0对所有药物活血和行气功效进行关联规则分析，并通过SPSS Statistics 26进行系统聚类分析。结果研究最终纳入177篇合格文献，涉及80篇加减方，97篇全方，共涉及4种药物类别，其中补虚药（16.7%），理气药（25%），活血化瘀药（41.6%），清热药（16.7%）。活血功效总频次为1078次，其中有7味中药使用频次≥110次，分别为桃仁（15.3%），红花（14.1%），丹皮（13.7%），赤芍（14.5%），当归（14.6%），五灵脂（11.1%），川芎（13.3%）。行气功效总频次为595次，其中有4味中药使用频次≥110次，分别为香附（25.5%），乌药（24.2%），枳壳（24%），延胡索（20.5%）。将使用频次≥110次的中药进行关联规则分析显示，7味中药归活血组，4味归行气组。甘草检所发现共有文献132篇，其中活血功效0篇，行气功效0篇，调和药性功效132篇。结论膈下逐瘀汤可以拆分为行气组和活血组，行气组包括香附、乌药、枳壳、延胡索，活血组包括桃仁、红花、丹皮、赤芍、当归、五灵脂、川芎，对膈下逐瘀汤活血组和行气组拆方做具体阐述，对其科学内涵进行深入研究，为经方应用研究提供新的视角。

英文摘要:

Objectives:System to organize and summarizes the diaphragm by blood stasis soup clinical prescription rule, analysis under the diaphragm by blood stasis soup in activating blood circulation and the principle of qi effect, explore Wang Qing qi theory of clinical and pharmaceutical research basis, establish the diaphragm by blood stasis soup group qi square theory basis, provide a reference for the same study.Methods: The database of CNKI (CNKI (Wan Fang), the VIP (VIP), retrieve all the application of 2 m from 2012 to 2022, extract the prescription name, drug composition, drug efficacy, and use SPSS Modeler18.0, and conduct systematic cluster analysis by SPSS Statistics 26.Results: In the study, 177 qualified documents, involving 80 prescriptions and 97 complete prescriptions, involved a total of 4 drug categories, including deficiency (16.7%), qi management (25%), blood circulation and blood stasis (41.6%), and heat-clearing drugs (16.7%). The total frequency of blood circulation was 1078 times, among which 7 Chinese medicines were used 110 times, including peach kernel (15.3%), safflower (14.1%), red skin (13.7%), red peony (14.5%), Angelica (14.6%), Wuling fat (11.1%), and Chuanxiong (13.3%). The total frequency of qi efficacy was 595 times, among which 4 Chinese medicines were used 110 times, including fragrant (25.5%), black (24.2%), fructus aurantii (24%) and further (20.5%). The analysis of 110 times showed that 7 Chinese medicines were in the circulation group and 4 in the qi group. A total of 132 documents were found, including 0 of blood circulation, 0 of qi, and 132 of medicinal efficacy.Conclusions:Under the diaphragm by blood stasis soup can be divided into xingqi group and blood circulation group, xingqi group including incense attached, wu, tus, hu, blood circulation group, including peach, safflower, skin, red peony, angelica, five spirit fat, chuanxiong, under the diaphragm by blood circulation group and line qi group do specific elaboration, in-depth study on the scientific connotation, provide a new perspective for the applied research.

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