| mTOR在非酒精性脂肪性肝病脂质代谢中的作用研究进展 |
| Research Progress of mTOR Signaling Pathway in lipid metabolism of NAFLD |
| DOI： |
| 中文关键词: mTOR通路 非酒精性脂肪性肝病 脂质代谢 |
| 英文关键词: mTOR pathway nonalcoholic fatty liver disease lipid metabolism |
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| 中文摘要: |
| 随着经济的发展和生活方式的转变,非酒精性脂肪性肝病(nonalcoholic fatty liver disease, NAFLD)已成为全球最普遍的肝脏疾病,是肝细胞癌的主要危险因素,也与二型糖尿病、心血管疾病等的风险增加有关。哺乳动物雷帕霉素受体(mammalian target of rapamycin, mTOR)通路处于细胞生长和代谢的中心, 参与许多代谢性疾病,大量研究表明,抑制mTOR对缓解NAFLD有益。本文就mTOR通路在NAFLD脂质代谢中的作用及研究进展进行综述如下。 |
| 英文摘要: |
| With the development of economy and the change of lifestyle, nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease in the world. It is a major risk factor for hepatocellular carcinoma and is also associated with the increased risk of type 2 diabetes and cardiovascular diseases. Mammalian target of rapamycin (mTOR) pathway is at the center of cell growth and metabolism and is involved in many metabolic diseases. A large number of studies have shown that inhibition of mTOR is beneficial for alleviating NAFLD. In this paper, the role of mTOR pathway in lipid metabolism of NAFLD and its research progress are summarized as follows. |
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