| 垂盆草颗粒联合伐昔洛韦治疗带状疱疹的疗效及对血清炎性因子的影响 |
| Efficacy of weeping herb granules combined with valacyclovir in the treatment of herpes zoster and its effect on serum inflammatory factors |
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| 中文关键词: 带状疱疹 垂盆草颗粒 伐昔洛韦 炎性因子 |
| 英文关键词: herpes zoster weeping herb granules valacyclovir inflammatory factors |
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| 中文摘要: |
| 目的 探讨垂盆草颗粒联合伐昔洛韦治疗带状疱疹的临床效果。方法 将94例于2022年1月~2024年1月南京市秦淮区夫子庙社区卫生服务中心接受治疗的带状疱疹患者通过随机数字表法的方式完成组别的划分，并分别命名为对照组、观察组，每组47例，对照组予以伐昔洛韦治疗，观察组予以垂盆草颗粒+伐昔洛韦治疗，对两组临床症状、血清炎性因子水平、治疗安全性予以比较。结果 治疗后，观察组皮损面积、视觉模拟评分法（VAS）评分、疱疹数目相较于对照组，改善更明显（P＜0.05）；治疗后，观察组血清白介素-1β（IL-1β）、肿瘤坏死因子（TNF-α）、白介素-6（IL-6）水平相较于对照组，下降的更加显著（P＜0.05）；不良反应发生率对比来看，观察组（12.77%）与对照组（8.51%）并无明显差异（P＞0.05）。结论 垂盆草颗粒联合伐昔洛韦治疗带状疱疹，可促进患者症状改善，降低炎性因子水平，且安全性良好。 |
| 英文摘要: |
| Objective To investigate the clinical effect of weeping herb granules combined with valacyclovir in the treatment of herpes zoster. Methods A total of 94 patients with herpes zoster who were treated at Fuzimiao Community Health Service Centers , Qinhuai District, Nanjing from January 2022 ~ January 2024 were divided into groups by random number table method, and named as control group and observation group, with 47 cases in each group, the control group was treated with valacyclovir, and the observation group was treated with weeping herb granules + valacyclovir, and the clinical symptoms, serum inflammatory factor levels and treatment safety of the two groups were compared. Results After treatment, the area of skin lesions, VAS score and number of herpes in the observation group were significantly improved compared with those in the control group (P<0.05), and the serum levels of interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the observation group decreased significantly compared with those in the control group (P<0.05), and the incidence of adverse reactions was compared with that in the control group (8.51%) ) (P>0.05). Conclusion The combination of weeping herb granules and valacyclovir in the treatment of herpes zoster can promote the improvement of symptoms and reduce the level of inflammatory factors in patients with good safety. |
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